Ceramide Accumulation

March 3, 2021

CERAMIDE ACCUMULATION, ACDase DEFICIENCY AND COVID-19?

Continuing from where we left off yesterday. More specifically, it appears that the METABOLIC VIRUS that is SARS-CoV-2 is focusing on Ceramide Metabolism. In particular, it may be focusing on dysregulating ACDase. This results in the accumulation of Ceramide in tissues. This explains the de novo diabetes onset. It even explains the hair loss seen in Long COVID patients. It explains the vision loss that is being observed in Long COVID and some acute COVID patients. Vascular leakage, lung compliance issues are all related to ACDase Deficiency. It can result in a fatal wasting disease (SMA-PME). This is preliminary. However, I am almost certain the virus is not a virus in the strict sense of the term. It is a vector that is inducing a Sphingolipid Metabolism disease.

Interestingly, symptoms/conditions of the VERY OLD can be synonymous with symptoms of the SUPER OBESE! 

  • osteoarthritis
  • heart disease and blood lipid abnormalities
  • stroke
  • type 2 diabetes
  • sleep apnea (when you periodically stop breathing during sleep)
  • reproductive problems
  • gallstones
  • certain cancers
  • obesity hypoventilation syndrome
  • metabolic syndrome
  • endocrine (hormone) problems
  • genetic syndromes
  • CHRONIC INFLAMMATION

Related/Referenced Papers

A perilous path: the inborn errors of sphingolipid metabolism

https://ncbi.nlm.nih.gov/pmc/articles/PMC6399501/

Spinal muscular atrophy with progressive myoclonic epilepsy

https://medlineplus.gov/genetics/condition/spinal-muscular-atrophy-with-progressive-myoclonic-epilepsy/

Systemic ceramide accumulation leads to severe and varied pathological consequences

https://ncbi.nlm.nih.gov/pmc/articles/PMC3779446/

Severe Bilateral Vision Loss in 2 Patients With Coronavirus Disease 2019

https://ncbi.nlm.nih.gov/pmc/articles/PMC7382416/

Systemic ceramide accumulation leads to severe and varied pathological consequences

https://ncbi.nlm.nih.gov/pmc/articles/PMC3779446/

Buildup of 'toxic fat' metabolite could increase diabetes risk

https://sciencedaily.com/releases/2016/11/161103122227.htm

The role of ceramides in metabolic disorders: when size and localization matters

https://www.nature.com/articles/s41574-020-0320-5?proof=t