SARS-CoV-2 AND ITS RELATION TO FELINE INFECTIOUS PERITONITIS

Feline Coronavirus (FECV) is a pathogen of minor significance; however, a spontaneous mutation of this virus yields FIPV, which is capable of replicating in peritoneal macrophages and producing peritonitis and occasionally FIP, a fatal Arthus-like pyogranulomatous disease in kittens and cats.

This is an extremely significant fact. In chess, you can begin a game in one opening, and by MOVE ORDER, TRANSPOSE into another opening. I believe looking at COVID and its relation to FIP in a similar way yields critical insight.

Whilst FIP invades MACROPHAGES in cats, SARS-CoV-2 invades MONOCYTES in humans. The only critical difference between macrophages and monocytes is where they are located. They both perform virtually the same functions. Macrophages are found in tissue. Monocytes are found in blood.

In cats, the virus invades MACROPHAGES in the PERITONEUM. Peritonitis is a redness and swelling (inflammation) of the tissue that lines your belly or abdomen. This tissue is called the peritoneum. It can be a serious, deadly disease.

In humans, the Spike Protein invades MONOCYTES in the BLOOD STREAM. I believe you can now logically follow the progression of disease. And, perhaps like FIP, this vasculitis only occurs in a fraction of those infected. Or, is it multiphasic in all those exposed to SARS-CoV-2?

I do not know. We need to examine monocytes of a very large segment of the population and study based upon known exposures to the Spike Protein.

What would be the mechanism of this? The hypothetical pathogenetic process for covid-19 could occur in three phases: a) Viral phase, asymptomatic or weakly symptomatic, with an a-specific innate immune response; b) Immunological phase, intermediately symptomatic, with an anomalous specific immune response (delayed, slow and/or low synthesis of IgM and IgG) in antigen excess conditions, immune complex formation and complement activation with tissue damages; c) Hemo-vascular phase, severely symptomatic, where complement-mediated tissue damages would induce vascular inflammation and systemic alteration of the coagulation homeostasis.

An Arthus-like reaction.

What is most interesting is that the markers for FIP in FECV cats, are also present in all COVID patients, and are markedly elevated in those with severe disease or those who die.

We may be dealing with another HIV – Human Infectious Vasculitis.

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