Juy 28, 2021
This lethal process (Ferroptosis) is defined by the iron-dependent accumulation of lipid reactive oxygen species and depletion of plasma membrane polyunsaturated fatty acids. The Spike Protein accomplishes this depletion by BINDING to Linoleic Acid which IS a n-6 polyunsaturated fatty acid.
If the spike crosses the BBB this is partcularly critical as Linoleic Acid in the brain has connections among serotonin, platelets, cytoskeletal proteins and other molecular interactions with implications regarding the genesis of the brain behavior.
Referenced/Related Papers
Mechanisms of ferroptosis
https://link.springer.com/article/10.1007/s00018-016-2194-1
Linoleic acid: Is this the key that unlocks the quantum brain? Insights linking broken symmetries in molecular biology, mood disorders and personalistic emergentism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395787/
The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour