December 31, 2021
Heretofore the global medical community has been mainly concerned with the Acute phase of COVID-19. This is in both aspects of treatment and prevention. However, I believe that the Acute phase of COVID-19 is only the very tip of a massive pathogenic iceberg. And one that continues to “build” upon itself.
A paper published November 12 identified kidney disease as the leading risk factor for hospitalization in confirmed COVID-19 patients. The phenome-wide association study also identified Type 2 Diabetes, Congestive Heart Failure, COPD in addition to Chronic Kidney Disease.
What is it that ties all of these diseases together? Please remember that Schizophrenia is also considered to be a major risk factor for severe COVID. All of the above pathologies have ENDOTHELIAL DYSFUNCTION at their core.
For example, coronary microvascular endothelial dysfunction (CMED) has been associated with increased mortality and a higher risk of major adverse cardiovascular events, including myocardial infarction, progressive congestive heart failure, and sudden cardiac death. I believe this is perhaps the single most important factor in the number of sudden cardiac deaths we are observing, especially in the young.
It would seem that MICROVASCULAR ENDOTHELIAL DYSFUNCTION may be at the core of COVID-19, making it a crossroads of Endothelial Pathology.
THE CONCERN
Each of the diseases discussed above are also ADVANCED by Endothelial Damage. My concern is that continual and/or repeated exposure to the Spike Protein will cause either the induction of or the progression of endothelial-involved pathologies.
Referenced/Related Papers
Endothelial dysfunction and pathogenesis of diabetic angiopathy
https://pubmed.ncbi.nlm.nih.gov/9217873/
Endothelial Dysfunction in Diabetes: Pathogenesis, Significance, and Treatment
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4063100/
Endothelial Dysfunction in Chronic Kidney Disease, from Biology to Clinical Outcomes: A 2020 Update
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7465707/
Coronary Microvascular Endothelial Dysfunction in Patients With Angina and Nonobstructive Coronary Artery Disease Is Associated With Elevated Serum Homocysteine Levels
https://www.ahajournals.org/doi/epub/10.1161/JAHA.120.017746
Neurovascular Unit Dysfunction and Blood–Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5440518/
COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series)
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5826015/
The novel coronavirus’ spike protein plays additional key role in illness
Electronic health record analysis identifies kidney disease as the leading risk factor for hospitalization in confirmed COVID-19 patients
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242182