May 10, 2021
The SARS-CoV-2 Spike Protein Disrupts Mitochondrial Metabolism The Same Way Cancer Does. This Increases L2-HG, Impairing T-Reg Cells, Hematopoietic Stem Cells and Causing Hypermethylation Of DNA/RNA
SARS-CoV-2 interacts with the mitochondria and impairs their metabolism. This disruption of the mitochondrial respiratory chain increases L2-hydroxyglutarate and loss of the chain in Treg cells increased DNA methylation as well as the metabolites 2-hydroxyglutarate (2-HG) and succinate that inhibit the ten-eleven translocation (TET) family of DNA demethylases. Treg cells require mitochondrial complex III (chain) to maintain immune regulatory gene expression and suppressive function. Mice given this mutation die of a severe inflammatory autoimmune disease weeks after birth. What is most interesting is that the NUMBER, PROLIFERATION and SURVIVAL of the T Regs are UNAFFECTED. Counts will be NORMAL.
Another effect of increased L2-hydroxyglutarate (2-HG) is that hematopoietic stem cells LOSE THEIR ABILITY to become PLURIPOTENT. This explains much of what we are seeing in Long COVID.
On the bright side, fruit flies with a similar disorder, when given L2HGDH, recovered from their deficits. Perhaps this may be an effective therapeutic for COVID and Long COVID.
Mitochondrial complex III is essential for suppressive function of regulatory T cells