January 31, 2022
It is one thing to plant a seed. It is another for it to grow successfully. It must have the right environment – and tumors must have the right microenvironment.
It has been established that the Spike Protein of SARS-CoV-2 impairs DNA Damage repair while simultaneously downregulating tumor suppressor proteins p53 and BRCA.
This is the “planting the seed” part of establishing micrometastatic disease without a primary tumor.
For those who are not familiar, most cancer patients die of METASTASIS. This is when their tumor spreads to other parts of the body and is almost universally initially undetectable. This is referred to as “occult metastasis.”
But, what would happen if you generated occult metastases WITHOUT having the initial tumor present?
You would indeed have an immense number of oncogenic “black holes” roaming your body. But, as I mentioned earlier, it is one thing to plant a seed. It is another to ensure that it grows. After all, most acorns do not produce an oak tree.
You need what is known as a “Tumor Microenvironment” for these “tumorlings” to grow in to tumors. And, what is paramount in a successful tumor microenvironment? THE TRANSFORMATION OF THE MICROVASCULAR SYSTEM TO PROMOTE MULTISTAGE TUMORIGENESIS.
Expression of SARS-CoV-2 antigens (including the Spike Protein) triggered an altered secretory pattern leading to a pro-inflammatory and pro-angiogenic microenvironment.
In contrast to the coordinated process of neovascularization during wound healing, tumors display extensive angiogenesis and fail to establish a well-differentiated, hierarchically organized vasculature.
This is exactly what is seen in COVID. A significantly enhanced amount of new vessel growth, through a mechanism of IA, has been reported in lungs of patients who died from Covid-19; among the angiogenesis-related genes, fibroblast growth factor 2 (FGF2) was found to be upregulated.
So, what does this mean?
I believe the combination of factors induced by the Spike Protein of SARS-CoV-2 may lead to the inducement of MICROMETASTATIC DISEASE – which would result in tumors appearing ANYWHERE.
The question: How Much Spike is Needed?
Referenced/Related Papers
Intussusceptive angiogenesis in Covid-19: hypothesis on the significance and focus on the possible role of FGF2
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7486971/
Detection and Clinical Importance of Micrometastatic Disease
https://academic.oup.com/jnci/article/91/13/1113/2543717
Transformation of the microvascular system during multistage tumorigenesis
https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.10074
S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study
https://www.sciencedirect.com/science/article/pii/S1936523320303065
SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro