IS MIS-C A “RECURRENT TOXIC SHOCK SYNDROME?”

February 7, 2021

The Spike Protein of the SARS-COV-2 virus is almost certainly a Superantigen. 

https://pnas.org/content/117/41/25254

There have been several documented cases of recurrent Toxic Shock Syndrome.

Recurrent Nonmenstrual Toxic Shock Syndrome: Clinical Manifestations, Diagnosis, and Treatment

https://academic.oup.com/cid/article/32/10/1470/466771

Note that the two requirements for recurrent toxic shock are the persistence of the Superantigen and the absence of neutralizing antibodies. Also note, children present with MIS-C at precisely the time that neutralizing antibodies to SARS-CoV-2 may wane. 1-3 weeks.

This is almost certainly proof that SARS-CoV-2 is a persistent, neurotropic infection in some.

The MILLION DOLLAR QUESTION. What turns an asymptomatic infection into a life-threatening Toxic Shock Syndrome weeks later????

Referenced/Related Papers

Sustained Positivity and Reinfection With SARS-CoV-2 in Children: Does Quarantine/Isolation Period Need Reconsideration in a Pediatric Population?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732141/

Toxic shock syndrome. Possible confusion with Kawasaki’s disease

https://pubmed.ncbi.nlm.nih.gov/7261671/