August 13, 2021

Epigallocatechin gallate (EGCG) compared favorably to quercetin, losartan, captopril, and carvedilol in its ability to reduce heart weight indices and cardiomyocyte apoptosis in rats with induced cardiac hypertrophy. However, only EGCG, quecetin, and carvedilol inhibited telomere attrition.

It has been indicated that carotenoids, omega-3-fatty acid, coenzyme Q10, selenium and vitamin D can reduce the rate of telomeric shortening. 

In conclusion, chronic exposure to NAC can delay senescence of diseased EC via hTERT activation and transient telomere stabilization, unless oxidative stress-associated cell damage has become irreversible.

Omega-3 fish oil supplementation, adequate folate through diet, and maintaining high vitamin D serum levels also have proven health-promoting effects and can similarly be endorsed.

Enjoying a Mediterranean diet, avoiding eating too many calories, and consuming fruits and vegetables with high antioxidant levels can all be endorsed, and if these strategies happen to increase telomere length as part of their gift to longevity and health, so much the better.

Referenced/Related Papers

Chronic treatment with N-acetyl-cystein delays cellular senescence in endothelial cells isolated from a subgroup of atherosclerotic patients

Association of nutraceutical supplements with longer telomere length

Influencing Telomere Length: The Long and Short of It