The key is Antiphospholipid Syndrome

August 3, 2022

I have been working continuously on reconciling the observed autoimmunity and amyloidosis. I had a breakthrough this evening. I have not been able to get the constant deluge of sudden “unexplained” deaths out of my mind. I have been looking into every possible mechanism, with none completely satisfying me, until now. I believe I have found another very significant piece of the puzzle.

Cardiovascular autonomic dysfunction is not uncommon in multiple sclerosis (MS) and is related to the involvement of the vegetative areas of cardiac innervations in the medulla oblongata. It has been suggested that this may contribute to the occurrence of sudden death in MS. In this case report, we present a patient with active relapsing–remitting MS who died unexpectedly due to the sudden onset of cardiac arrythmias. Post-mortem examination showed the presence of active demyelinating lesions in the medulla oblongata. As far as we know, this is the first case report clearly linking sudden cardiac death to active MS on the histopathological level.

Sudden cardiac death in multiple sclerosis caused by active demyelination of the medulla oblongata

More convincingly, in another autopsy study of deceased COVID-19 patients, SARS-CoV-2 RNA and proteins (nucleocapsid or spike) were detected in 50% and 40% of brainstem samples, respectively.36 Similarly, another autopsy study has found SARS-CoV-2 RNA and spike proteins in the olfactory mucosal-neuronal junction and brainstem’s medulla in 67% and 19% of samples, respectively.37 In sum, these autopsy studies have provided evidence for SARS-CoV-2 tropism from the olfactory system into the brainstem.

Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis

I also believe this is paramount in PASC.

The researchers measured levels of immune messengers called cytokines and other biomarkers in the cerebrospinal fluid (CSF) of the mice. Then, they sectioned their brains to measure demyelination by using a transmission electron microscope to examine neurons in a region of the brain called the corpus callosum. As expected, in the mice with mild COVID-19, “we found white matter-specific microglial reactivity, a dropout of [myelin-producing] oligodendrocytes, impairment in myelin, and inhibition of new neuron generation in the hippocampus, just as predicted,” she says. “All of these things we had previously associated with this toxic microglial activity [in CRCI].” All this occurred without the virus infecting the brain itself.

Brain Fog Caused by Long COVID and Chemo Appear Similar

I wanted to get these findings out ASAP, as I believe they are critical. I am working on a more detailed explanation.