May 19, 2021

Depletion of ACE2 by the SARS-CoV-2 Spike Protein (via autoimmunity) inhibits immune cells from creating antibodies, causes endothelial dysregulation, impairs male reproduction and impair immune response. 

Children are initially spared as they have more ACE2 than adults. Reinfections/exposure to the Spike Protein depletes this over time. 

Referenced/Related Papers

Angiotensin-converting enzyme in innate and adaptive immunity