January 30, 2021
A paper from last December piqued my curiosity:
COVID-19 and anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis: Are we facing an increase in the prevalence of autoimmune encephalitis?
What could be causing such a very specific autoimmune encephalitis?
The Spike Protein of SARS-CoV-2 is inducing Glutamate Excitoxivity:
Glutamate Excitotoxicity Is Involved in the Induction of Paralysis in Mice after Infection by a Human Coronavirus with a Single Point Mutation in Its Spike Protein
This excitoxiticy is inducing the creation of anti-NMDA-NR1 antibodies and anti-NMDA-NR2A/B antibodies:
Glutamate receptor antibodies in neurological diseases
I believe this the cause for a vast majority of the neurological problems we are seeing in the acute phase and in Long COVID.
These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy.