SARS-CoV-2 MAY REPROGRAM CELLS TO RAPIDLY INCREASE METABOLIC RATE

June 8, 2021

If one examines the therapeutics which are beneficial in treating COVID-19, one is struck by a certain similarity – they all slow metabolism.  This should come as no surprise as the original SARS  preferred our own ATP. The SARS-CoV Hel hydrolyzed all eight common NTPs and dNTPs, exhibiting a marked preference for ATP, dATP, and dCTP. 

Most interesting is the observation that Remdesivir is NOT AN ANTIVIRAL in the case of SARS-CoV-2. Instead, IT BINDS BETTER TO OUR ATP THAN THE VIRUS’ POLYMERASE.

This may also explain the cardiac issues occurring with COVID-19 as there may be a mismatch in myocardial ATP supply and demand. This occurs in OBESITY.

It may be that we need to temporarily inhibit our metabolism to allow the body to clear the virus. 

Could it be that those who suffer from Long COVID have had epigenetic changes affecting ATP production? Could ATP be toxified by the virus as it becomes a mortal enemy in severe COVID? 

DOES THE BODY ENTER INTO A STATE OF HYPOXIA TO AVOID “FEEDING" THE VIRUS?

The body is often far craftier than we can know.

Referenced/Related Papers

ATP hydrolysis analysis of severe acute respiratory syndrome (SARS) coronavirus helicase

https://covid19.elsevierpure.com/it/publications/atp-hydrolysis-analysis-of-severe-acute-respiratory-syndrome-sars

The Severe Acute Respiratory Syndrome (SARS) Coronavirus NTPase/Helicase Belongs to a Distinct Class of 5′ to 3′ Viral Helicases*

https://jbc.org/article/S0021-9258(20)83004-X/fulltext#seccestitle30

Myocardial Energetics in Obesity

https://ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.042770#

Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase

https://www.sciencedirect.com/science/article/pii/S2589004220310464