SPIKE: HYPERACCELERATED AGING BY MANIPULATING THE TOR/FOXO AXIS.

August 1, 2021

Corticosteroids synergize FOXO. This is what PUTS THE BRAKES on the aging process in our bodies. Dexamethasone is a corticosteroid. It also works wonders in COVID-19 disease.

HYPERACCELERATED AGING IS BEING MISINTERPRETED AS NEURODEGENERATION

Although energy (ATP) is singularly highlighted
in the above examples, aging may better reflect a “complex interplay” among energy metabolism,  oxidative damage, calcium overload and cell death. Although discussed in the context of neurodegeneration, this perspective may generally apply to circumstances of high cellular stress.

THE NUMBER OF HEARTBEATS

Despite required refinements, a metabolic basis
of aging is  supported by facts such as that the number of heartbeats for a mouse and an elephant really are roughly the same.

WHAT IS A HALLMARK OF LONG COVID?

Tachycardia.

Not to be oversimplistic, yet this has immense meaning in the context of COVID and Long COVID. IVERMECTIN SLOWS METABOLISM

This, ultimately, is why Ivermectin works. I believe there are other compounds that can slow metabolism, and prove beneficial against SARS-CoV-2. 

WHY THE OBESE ARE MORE SEVERELY AFFECTED

The relationship of body mass to metabolic rate, however,  is one of the strongest known allometric relationships. Thus, r2 values of at least 0.95 were obtained in one of these studies and body mass accounts for nearly 97% of variation in metabolic rate across mammalian species.

THE VIRUS HYPERACCELERATES METABOLISM. AND STEALS THE FRUITS OF ITS LABOR, RESULTING IN SEVERE COVID

ATP shortfalls, however, generally compromise most cellular functions including ubiquitin-proteasome and NAD-dependent functions. These include glutathione reductases, thioredoxin, P450 enzymes, PPAR, SIRT, and NOX. Energy  shortfalls also engage stress pathways such as the unfolded protein response and hypoxia. Varying levels of energy may have complex impacts on systems that have evolved priorities in functional maintenance. Some variation among aspects of functional versus demographic aging may be rooted here.

The Spike Protein is hyperactivating mTOR. The destructive metabolic arm that must be kept in balance.

A paper out June 9 discusses how the Spike Protein downregulates Forkhead Transcription Factors (FOXO) and suggests their use may be beneficial against SARS-CoV-2. This is the protective metabolic arm of sleep needed to counteract TOR.

Accelerating our aging is undetectable, until it is too late. If action is not taken soon, Montagnier will be right about cremating the bodies, perhaps not for the reasons he envisioned. Then again, his model fits this one, as well.

Referenced/Related Papers

Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19

https://royalsocietypublishing.org/doi/10.1098/rsob.210069

Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956433/

An evidence that SARS-Cov-2/COVID-19 spike protein (SP) damages hematopoietic stem/progenitor cells in the mechanism of pyroptosis in Nlrp3 inflammasome-dependent manner

https://www.nature.com/articles/s41375-021-01332-z