August 6, 2021

The paper published June 15th detailed loss of matter in the brain from even mild COVID disease. I read the paper this morning and have not been able to get it out of my mind. Let us think about all the CATABOLIC issues with COVID, and especially Long COVID. Muscle wasting, accelerated metabolism, accelerated aging. In a word, accelerated. And. Wasting. The body is devouring itself as all tests for SARS-CoV-2 are negative at this stage. Autophagy is critical for natural disassembly of unnecessary or dysfunctional components in cells. Appropriate autophagy allows for recycling of cellular components and organelles, thus maintaining cell functions. However, aberrant autophagy can lead to cell dysfunctions and even death. It appears that those actions which induce autophagy, low carb, exercise, are indeed beneficial INITIALLY. However, a good thing, under the auspices of SARS-CoV-2, becomes too much of a good thing and the serpent eats itself. Ouroboros.

So it very well may be that the fit (AND CHILDREN!) SEEM to be spared, but upon infection and reinfection, the aberrant autophagy continues anon. One may compare the situation to that in the First Player’s speech of Hamlet:

But as we often see against some storm
A silence in the heavens, the rack stand still,

The bold winds speechless, and the orb below
As hush as death, anon the dreadful thunder
Doth rend the region. So, after Pyrrhus’ pause,
Arousèd vengeance sets him new a-work.
And never did the Cyclops’ hammers fall
On Mars’s armor forged for proof eterne

With less remorse than Pyrrhus’ bleeding sword
Now falls on Priam.

And so HMGB1, (the DAMP associated with initiating aberrant autophagy), is the Cyclops’ hammers that sound out the signals to destroy our cells, with aroused vengeance! And, what is elevated in COVID? 


And what elevates HMGB1? 


This finally explains the insulin resistance which is ubiquitous in COVID and the associated new onset diabetes. This also helps explain the involvement of TLR4.

The time to act is quickly running out.

Referenced/Related Papers

HMGB1-induced aberrant autophagy contributes to insulin resistance in granulosa cells in PCOS 

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells