SARS-CoV-2 AND TRANSCRIPTIONAL/TRANSLATIONAL ERROR

May 4, 2021

THIS EXPLAINS CANCER/CACHEXIA, DIABETES, NEURODEGENERATION AND WHY PRION DISEASE IS ITS ULTIMATE DESTINATION

Transcription errors sensitize cells to genes associated with protein-folding diseases. These diseases include Parkinson’s, ALS, and, of course, Prion Disease. Transcription errors increase with age. By the same token, INCREASING TRANSCRIPTION ERRORS INCREASES AGE.

What is most fascinating is that Transcription errors decrease the lifespan of cells, which can be rescued by DIETARY RESTRICTION. 

Proteotoxic stress allows proteins associated with neurodegenerative diseases to escape the surveillance of the protein quality control machinery. 

If you read anything today, please read the referenced paper by Vermulst, et al. Also, the paper by Wickner.

The translation – associated chaperones, both the intrinsic ribosomal chaperone activity and the ribosome-associated Ssb Hsp70s, have important effects on prion generation and propagation. 

HSPs are GREATLY ELEVATED in COVID-19. These are the molecular chaperones that can misfold proteins.

THE SOLUTION TO “CANCER WITHOUT TUMORS"

SARS-CoV-2 CAUSES CELLS TO INITIATE THE FATAL PROCESSES OF CANCER AND NEURODEGENERATION BYPASSING THEIR NATURAL COURSE OF DEVELOPMENT.

Referenced/Related Papers

Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients

https://ncbi.nlm.nih.gov/pmc/articles/PMC7314329/

Transcription Errors Induce Proteotoxic Stress and Shorten Cellular Lifespan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684168/

Abnormalities in Stress Proteins in Prion Diseases

https://link.springer.com/article/10.1023/A:1020646321841