September 12, 2021
We have been overwhelmed with hypotheses trying to determine exactly what COVID-19 is. I, myself, am certainly a generous contributor to this tsunami of conjecture as to what exactly is happening pathologically in a SARS-CoV-2 infection. This is understandable as the disease manifests itself with such a wide variety of symptoms.
And this is the point. It is a
MULTI-SYSTEMIC DISEASE. As with all other multi-systemic diseases, there is no
concrete order for the appearance of symptoms as everyone will have symptoms
present in accordance with their respective genetics. The end results will be
the same, the roads traveled to reach those results will be unique.
If we look at the iron overload factor alone, this is a major clue. Iron
homeostasis is intimately related with alpha-synuclein. A protein which can
misfold, just like a PRION. But, it is NOT a PRION. It can become what we know
of as a LEWY BODY. These misfolded proteins can aggregate (clump together).
This is when they interfere with cellular functions.
Parkinson’s Disease is a possible result of Lewy Body aggregation, and, indeed, we see many Parkinsonian features in COVID-19 disease, yet the diagnosis is not satisfactory as there are many other elements and systems involved in COVID-19 disease.
This is where I started delving into multiple system diseases. The answer had to be found there. After exhaustively studying multi-system diseases and knowing of the neurological symptoms of COVID-19, it appeared to me that, ultimately, we are looking at a novel variant of Multiple System Atrophy (MSA).
The good news? You can live with it for around nine years. The bad news? It is 100% fatal.
This is not to fear monger, but to underscore the severity of what we may be dealing with. Perhaps this version is treatable and reversible as it may be related to CONSTANT SIGNALING of the spike protein. Remove all the spike proteins from the body, or silence them, the condition resolves. Think of the spike protein as latent HIV – you get the picture.
What most attracted me to MSA as a likely candidate was the overexpression of miRNA hsa- ir-16-5p. This is the most overexpressed miRNA in MSA – it is also a miRNA intimately related to ACE2.
Of course, that is not all, not in the least. The relation of Iron and MSA is extremely important. MSA has appeared in patients with Schizophrenia. Autopsies of MSA patients show T-cell infiltrations. So do COVID-19 autopsies. SARS-CoV-2 neuroinvasion is believed to cause aggregation of alpha-synuclein, MSA is considered to be a synucleinopathy. Posterior Reversible Encephalopathy Syndrome is observed in MSA, and in COVID-19.
Of course, the symptoms of Long COVID themselves are perfectly aligned with MSA. And, they include those with distinct differences from Parkinson’s. Unique features: Important differences distinguish the symptoms and course of MSA from Parkinson’s disease and other conditions of the nervous system, such as cerebellar ataxia or pure autonomic failure (PAF).
Notably, MSA affects several areas of the brain, including the cerebellum,
the brain’s balance and coordination centers, and the autonomic nervous system.
I believe the Spike Protein will be found responsible for Long COVID/MSA.
Distinct from the “respiratory” acute phase, which may be more
linked to the N protein.
Referenced/Related Papers
ACE2 Interaction Networks in COVID-19: A Physiological Framework for
Prediction of Outcome in Patients with Cardiovascular Risk Factors
MicroRNA Deregulation in Blood Serum Identifies Multiple System
Atrophy Altered Pathways
https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28143
Accumulation of alpha-synuclein/NACP is a cytopathological feature
common to Lewy body disease and multiple system atrophy
Possible multiple system atrophy with predominant parkinsonism in a
patient with chronic schizophrenia: a case report
https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-018-1714-y
Deep spatial profiling of human COVID-19 brains reveals
neuroinflammation with distinct microanatomical microglia-T-cell interactions
Possible Link between SARS-CoV-2 Infection and Parkinson’s Disease:
The Role of Toll-Like Receptor 4
SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril
formation
Posterior Reversible Encephalopathy Syndrome in a Patient With
Multiple System Atrophy
https://movementdisorders.onlinelibrary.wiley.com/doi/full/10.1002/mdc3.12495
Current Symptomatic and Disease-Modifying Treatments in Multiple
System Atrophy
The Relevance of Iron in the Pathogenesis of Multiple System
Atrophy: A Viewpoint