August 15, 2021
One sentence in one paper has so far been completely hidden, yet it is one of the most important sentences of the pandemic:
Similarly, HNRNPD (aka AUF1), a protein known to inhibit enteroviruses through degradation of the viral RNA17, was depleted in SARS-CoV-2 infected cells.
What is AUF1? An extraordinarily important heterogeneous nuclear ribonucleoprotein which regulates nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. In this case, AUF1 regulates (is supposed to "put the brakes on") inflammatory response and TELOMERE MAINTENANCE. In terms of mRNA therapy, it is responsible for mRNA DECAY. It is also regulates G-Coupled Receptor Signaling, which is intimately involved in SARS-CoV-2.
There is a third aspect to AUF1's influence - Cancer. It is involved in prevention of the Invasion, Proliferation and Metatstasis of Cancer.
It has been shown that the Spike Protein is very likely responsible for the inhibition of Telomerase. We must immediately determine its impact on AUF1 expression. I can find no studies referencing its involvement anywhere in the literature.
Referenced/Related Papers
Sars-Cov2 Spike and Telomerase RNA’s Compared to Arrive at an Explanation for Increased Ageing in Alveolar Cells in Severe COVID-19
SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAKSTAT pathway
https://www.biorxiv.org/content/10.1101/2020.10.27.358259v1.full.pdf
The hnRNP family: insights into their role in health and disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947485/